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    Dr. Misha Blagosklonny published
    Предложение | 16.10.2019, 19:06

    Misha V. Blagosklonny graduated with an MD and PhD from First Pavlov State Medical
    University of St. Petersburg, RUS. Dr. Mikhail V. Blagosklonny has then
    Immigrated to the United States, where he was
    Awarded the prestigious Fogarty Fellowship from the National Institutes of Health.
    Within the period of his fellowship in Leonard Neckers’ laboratory at the National
    Cancer Institute (NCI), he was a co-author of 18 publications on
    Diverse biomedical topics, suchas targeting
    HSP90, p53, Bcl2, Erb2, and Raf-1. He also was the last writer on a clinical phase I/II
    Trial paper.
     
    After authoring seven papers during a brief yet resulting
    Senior research fellowship in the El-Deiry Cancer Research Lab at the University of Pennsylvania,
    Dr. Blagosklonny returned to NCI to work with Tito Fojo. Together, they
    Published 26 papers. Moreover, Dr. Mikhail Blagosklonny published anumber of experimental research articles and theoretical articles as sole
    Author. The abovementioned sole-author publications
    Included two crucial themes.
    The first of those discussed selectively killing cancer
    Cells with deregulated cell cycle or drug resistance by
    Validation their resistance. The outcomes and underlying
    Notion were so revolutionary that they were incorrectly cited by
    Other scientists as “reversal of resistance, ” even though the article was
    Named, “Exploiting of drug resistance instead of its reversal. ” One great
    Supporter of this concept was the world-famous scientist Arthur Pardee, with whom Dr.
    Blagosklonny co-authored a joint article in 2001.
     
    The second theme throughout Dr. Blagosklonny’s sole-author articles
    Is a research method to produce knowledge by
    Uniting a few facts together from seemingly unrelated fields.
    This results in new concepts containing testable forecasts, which in
    Turn can be “tested” by analyzing the literature further. Likewise, the
    Notion was co-authored by Arthur Pardee in a 2002 article in Nature. The
    First success of the new research methodology was the description of the feedback
    Regulation of p53, as supported by the discovery of mdm2/p53 loop; and the
    Explanation why mutant p53 is always overexpressed, published in 1997. The most
    Important result discovered by Dr.
    Blagosklonny’s research methodology is the hyperfunction (or quasi-programmed)
    Theory of aging and the revelation of rapamycin as an exclusively well-tolerated
    Anti-aging medicine, published in 2006. As mentioned in Scientific American,
    Michael Hall, who discovered mTOR in 1991, gives Dr. Blagosklonny credit for
    “connecting dots that others do not even see. ”
     
    In 2002, Dr. Blagosklonny became associate professor of medicine at New York Medical College.
    He agreed to accept responsibilities as a senior scientist at Ordway
    Research Institute in Albany, New York, in 2005, prior to receiving another
    Position at Roswell Park Cancer Institute as professor of oncology in 2009.
     
    Since joining Roswell Park Comprehensive Cancer Center in 2009, Dr. Blagosklonny
    Has studied the prevention of cancer (an age-related disease) by
    Inhibiting body aging — in other words, “preventing cancer
    Via remainng young. ” His lab closely collaborated with
    Andrei Gudkov’s and performed research on the suppression of
    Cellular senescence, namely suppression of cellular conversion from healthy quiescence to
    Permanent senescence. This resulted in the discovery of additional anti-aging
    Medications beyond rapamycin. The cell culture studies were
    Complemented by studies in mice, including several models such as
    Standard and aging mice, p53-deficient mice, and mice on a high-fat diet.
     
    Dr. Misha Blagosklonny has also published extensively on the stoppage of cellular
    Senescence by rapamycin as well as other mTOR inhibitors, life
    Prolongation and cancer cure in mice, and combinations of anti-
    Aging medicines to be used in humans. A
    Rapamycin-based combination of seven clinically available medications has
    Been named the “Koschei Formula” and is now used for the treatment of aging in patients
    At the Alan Green Clinic in Little Neck, New York.

     

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